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BACKGROUND: A popular objective of many high-throughput genome projects is to discover various genomic markers associated with traits and develop statistical models to predict traits of future patients based on marker values.
Linkage analysis relies on evaluation of genomic markers to identify the region of the genome that segregates with the disease.
Garnett, M.J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells.
Garnett, M. J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells.
Sheu, J.J. et al. Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 are genomic markers for prognosis of advanced nasopharyngeal carcinoma.
These included genomic markers for the β-actin and TP53 tumor suppressor gene.
Even for diseases that have these big 'red flag' genomic markers, HEAL could offer a leg up, Snyder said.
Recent evidence suggests that two genomic markers, KIF6 and SLCO1B1, may inform the therapy choice of patients initiating statins.
The next stage is to combine this vital sign data with other predictive data – such as genomic markers for conditions like breast cancer – to devise personalised treatment programmes tailored to a patient's risk profile.
Marker-assisted breeding (usually called marker assisted selection) uses the genetic diversity found in crops or their wild relatives, combined with genomic data (genomic markers) to speed up what are otherwise essentially conventional breeding methods.
Faucon, F. et al. In the hunt for genomic markers of metabolic resistance to pyrethroids in the mosquito Aedes aegypti: An integrated next-generation sequencing approach.
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