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We approach the analysis of genomic loss slightly differently, though with a similar conceptual framework.
A total of nine pleomorphic liposarcomas have genomic loss at this locus, eight are hemizygous and one is homozygous.
Thus far, this is a feature unique to genomic loss and complicates the detection of hemizygous loss when its transition from wild-type signal appears featureless.
Since no genomic loss was observed on the chromosome 16q13 region in our ependymoma samples, this downregulation was more likely to be linked to transcriptional inactivation.
Using this strategy we report for the first time, identification of miR-218 (hsa-miR-218; MIMAT0000275) located within a region of genomic loss (4p15.31 and 5q35.1) as a putative tumour suppressor in non-small cell lung cancer (NSCLC).
Their conclusion was based on the analysis of 40 genes in the MCF10CA1a cells; they found 13 up and 18 down regulated genes in genomic gain regions whereas 3 down and 6 up regulated genes in the genomic loss regions.
Furthermore, they found that changes in miRNA expression correlate with genomic loss or gain.
We investigated the genomic loss frequency of 6q24 in various subtypes of non-Hodgkin lymphoma.
17 In that study, we observed that 67% of PTTL cases showed genomic loss at 6q24.2.
Genomic loss of 6q24 was observed in 14 of 232 (6%) PTCL cases.
The genomic loss regions identified at 6q24 always involved only two known genes, STX11 and UTRN.
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