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Overexpression of the HER2 protein without amplification at the genomic level has been described previously to be rare [ 24].
Indeed, the prevalence of splice variants at the genomic level has been assessed, suggesting a potential role for the regulation of alternative splicing in different stages of disease, and particularly in cancer [ 56, 57].
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Similar genome-wide studies of integration of characters at the genomic level have been conducted for morphological traits (Klingenberg et al. 2004; Miller et al. 2014).
Additionally, several field experiments designed to measure selection at the genomic level have now been implemented in T. cristinae.
To our knowledge, no studies of nutritional regulation of chicken adipose tissue at the genomic level have been reported in the published literature.
As a consequence, differences between the rodent parasites especially at the genomic level have not been fully elucidated as yet and thus linking genomic differences to phenotypic traits of these parasites have been difficult.
While c-myc alterations on the genomic level have been reported in prostate [ 13- 15] and bladder cancer [ 16], DNA copy number changes of c-myc have been identified only in papillary, but not in clear cell RCC [ 17- 19].
At the genomic level, Dictyostelium has two characteristics which make them helpful for the further study on intron evolution.
At the genomic level there has been extensive gene loss, leading to many genes being present as single-copy genes besides some having two or three paralogs [ 6].
Such approaches could now be further developed to link cellular behavior in vivo with a molecular level analysis, because single-cell genomic level analysis has become feasible (Navin et al., 2011).
The accession pair India7-Syria are very different at the genomic level but have similar metabolic phenotypes, and could have resulted from convergent evolution driven by common selection on genotypes with the same metabolic potential.
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