Multiple rounds of polyploidization or large segmental duplication followed by gene loss, however, can greatly obscure the synteny, impeding the transfer of genomic knowledge from model species genomes to those of less well characterized species.
Following the relative disappointment for the slow pace of translation of genomic knowledge into clinical practice, genomics is in fact experiencing now a major come back driven largely by the unprecedented leap in our ability to sequence individual genomes.
Recognizing this problem and its clear pertinence to genome-scale biology, the research community began defining ontologies to capture and structure functional genomic knowledge even before the first human genome was fully sequenced [ 2- 4].
To add to genomic knowledge of this species and the evolution of teleosts, the genome of a Malaysian specimen of arowana was sequenced.
In all, we have demonstrated how to manage evolving genomic knowledge concepts and discovery results using data modeling techniques extended into the genomics domain.
Another issue that may be clarified with better genomic knowledge is the strange path of human evolution.
Genomic knowledge is assisting drug discovery in many ways.
Hyde praises projects like General Public Licenses, which channel intellectual property into the public domain, and the Distributed Annotation System, which prevents the monopolization of genomic knowledge.
ONE way of trying to make money out of the new genomic knowledge has been to offer what has come to be known as "personal genomics".
Dr. Kass, who is chairman of President Bush's new Council on Bioethics, said some larger questions about the human genome project might have been inadequately addressed up to now, including "the meaning of genomic knowledge for human self understanding and the understanding of families, genealogy and race".
Next, before dipping into the scientific complexities of how DNA operates the organism, the designers draw attention to the possible impact of the new genomic knowledge with a wall of scrolling headlines predicting such possibilities as the conquest of disease and parental choice of children's attributes.
