Sentence examples for genomic interaction is from inspiring English sources
Interestingly, this histological and genomic interaction is capable of spanning tumor initiating events from different mouse models.
A knowledge-driven genomic interaction is defined as one that uses information from biological knowledge databases coupled with patient genomic profiles for model development.
These observations suggest that REST and CoREST genomic interactions are highly complex and provide further support for the existence of a neuronal lineage-specific regulatory hierarchy for REST and CoREST that employs differential DNA binding motifs to encode functional information [19].
Thus, a large fraction of the genomic interactions are likely to be with regions that are not strongly selected on an evolutionary timescale.
Thus, the questions of how the chromatin organization changes upon environmental stimulation such as hormone and chemicals and how these genomic interactions are associated with disease development and progression remains elusive.
Our study has illustrated a method for uncovering genomic interactions that is easily applied in an experimental setting, is comparative, and requires no a priori knowledge of interactions (although such knowledge is useful for interpreting the changes).
The interaction matrix after normalization is presented in Additional file 4. The peaks in the genomic interaction profile were identified using a previously published algorithm [ 16].
The average chemical genomic interaction scores are provided in the supplemental information (Additional file 2: Table S2).
The key to understanding this multifaceted network of genomic interactions has been the identification of common genomic features, ie. promoters and enhancers.
These studies conclude that mining for dense subgraphs of significant genes within interaction networks can reveal modules of genomic interactions that are functionally relevant to specific phenotypes of interest.
From the analysis of Hi-C data, Botta et al. discovered that strong long-range genomic interactions could be maintained through the activity of the CCCTC-binding factor (CTCF) [ 17].
