Exact(10)
The genomic instructions used to regulate development are encoded within a set of functional DNA elements called cis-regulatory modules (CRMs).
The genomic instructions merely help to push the equilibrium in the direction of higher nucleosome occupancy.
CPU time needed to execute genomic instructions is the basic resource organisms compete for.
By integrating environmental signals with genomic instructions, epigenomes are instrumental in bridging genotypic variation and phenotypic diversity.
This map shows that all the genomic instructions that, when deleted, knock out the OR function also knock out the EQU function.
Several factors affect the binding of the nucleosomes: steric effects, competing molecules (such as transcription factors), nucleosome remodeling complexes, and genomic instructions.
Similar(50)
To create a genomic library the instructions of NEBNext protocol (E6240, Biolabs) was followed.
Single-molecule DNA fibres were prepared by molecular combing (34) according the manufacturer's instructions (Genomic Vision).
Single-molecule DNA fibres were prepared by molecular combing [ 33] according the manufacturer's instructions (Genomic Vision) using fibroblast cells of a Duroc boar.
RNA was then extracted following the manufacturer's instruction; genomic DNA removal was performed using the Ambion DNase I kit (Ambion) at 37°C for 10 min.
According to the manufacturer's instruction, genomic DNA was extracted from 2 µL of frozen peripheral blood and bisulfite treated using an EZ DNA Methylation Direct Kit (Zymo Research Corp., Irvine, California, USA); 1 µL of the resulting 10 µL bisulfite-treated genomic DNA solution was then subjected to PCR to amplify the GR promoter 1-F region, as described previously.
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