Sentence examples for genomic function of from inspiring English sources
In view of the fact that we found SIRT1 localized in 22 to 28% of cardiomyocytes nuclei, with the aim of understanding the nuclear genomic function of this deacetylase, we performed genome-wide profiling of its binding to DNA in the hearts of WT or mIGF-1 Tg mice by using ChIP-Seq and a specific ChIP-grade commercial antibody.
Although the vertically delivered DNA vector was not 100% efficient in the F0 (Table 1), at the cohort level, the vertically delivered DNA vectors could be used to study genomic function of a targeted gene in vivo (Table 2 and 3) without creating transgenic lines.
Integrating the analysis of the cistrome of a transcription factor by ChIP-Seq with the study of its transcriptional output by microarray or RNA-Seq analysis is a powerful approach to elucidate the genomic functions of a transcription factor.
In addition to the genomic functions of GC, non-genomic modes of GC regulation have been documented.
Genomic functions of the retinoids are mediated via their nuclear DNA-binding receptors, RARs, and RXRs, which regulate gene transcription through recruitment of corepressors and coactivators.
Variations on the genomic functions of GC include transcriptional regulation at the level of protein-protein interactions between the GR and other transcription factors, co-activators or co-repressors.
We propose that the requirement for both the rapid and genomic functions of PR during the regulation of miR-16 expression by progestins, as demonstrated in our study, may be explained by the fact that after being rapidly activated by PR, Stat3 is recruited, along with PR, to the PRE at the c-Myc promoter, where it acts as a PR co-activator (Step 3).
Although the non-genomic function of ER α in the absence of BRCA1 needs further investigation, our data suggest that IGF-1 might be produced at higher levels in breast cancers with a loss of BRCA1 function, which may induce a 'positive-feedback loop' in activating IGF-1R/PI3K/AKT/ER α signaling.
Several non-genomic functions of VD3 have previously been determined, some of these functions included insulin secretion, smooth muscle migration and opening calcium and chloride channels.
Of great interest, in contrast to other steroidal receptor co-regulators, PELP1 is involved in both genomic and non-genomic functions of steroidal signaling and exhibits oncogenic properties [ 7].
