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Copy number estimation is also an important factor for the genomic function analysis related to CNVs.
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A novel function for Ets-1 was elucidated in this study following genomic and functional analysis of an ovarian cancer Ets-1 expression model.
The availability of large-insert genomic DNA libraries is essential for physical analysis of large chromosomal regions, map-based gene isolation, and gene structure and function analysis.
Integrating the analysis of the cistrome of a transcription factor by ChIP-Seq with the study of its transcriptional output by microarray or RNA-Seq analysis is a powerful approach to elucidate the genomic functions of a transcription factor.
Several centrosome components have been identified recently, through proteomic studies or functional genomic analysis and their localization and function characterized [ 7- 9].
Functional genomic analysis is a challenging step in the so-called post-genomic field.
The "pan-genomic sequence analysis" function of PanSeq [ 36, 37] was run on the twelve reference genomes using default parameters except that "coreGenomeThreshold" was set at 11.
Whether the mapped qWL6 gene is a homologous gene of known function or a new gene encoding a protein of unknown function should be determined by a genomic sequence analysis and functional complementation assays.
In this study we report the application of an analysis pipeline which combines genomic comparative analysis and gene function prediction to finely characterize microbial genomes.
In addition, genomic comparative analysis and gene function prediction led to the identification of genetic changes in the capsule locus that could have contributed to pathogenicity.
The developed database provides genomic resource to grape community for functional analysis of genes in the collection and for the grape genome annotation and gene function identification.
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