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The selected papers in this Supplement issue represent the genomic focus in ICIBM 2012.
Particularly in the transition to a genomic focus in medicine, we recognize factors that are individually more modest in their impact than those highly penetrant alleles amenable to earlier genetic analyses.
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Currently, the majority of structural genomic projects focus on the soluble proteins, the "low-hanging fruit", due to their relative ease of expression, purification, and crystallization.
Recent studies provide evidence that corticosteroids can induce rapid non-genomic effects focused on immediate resolution of the stressful situation, followed by slower genomic effects focused on long-term recovery after stress.
We limit the scope to genomic data, focusing on large and complex genomes, for transcriptome assembly we refer to Martin and Wang (2011) and Wolf (2013).
With the recent release of several new complete haloarchaeal genome sequences, we have conducted a comprehensive comparative genomic analysis focusing on the identification of unique haloarchaeal conserved proteins that likely play key roles in environmental adaptation.
We assessed the degree of conservation between the chestnut genome and other well annotated and assembled plant genomic sequences, focusing on the QTL regions of most interest to the chestnut breeding community.
Ahmed et al 19 present a genomic analysis focused on the comparison of several assembly genome approaches in HPC scenarios.
The advent of whole genome sequencing allowed the scaling up of these approaches to 'reverse genomics.' Here we describe some of what has been learnt from reverse genomic approaches, focusing on comparative genomic studies.
We discuss the incorporation of genetic and genomic data, focussing on the recently sequenced Schistosoma spp., into novel mathematical transmission models to inform our understanding of the impact of MDA and other control methods.
Genomic analysis focused on the catabolic potential of this bacterium against several lignin-derived compounds.
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