Gaining a detailed understanding of the features underlying microsatellite genomic structure will aid subsequent interpretations of data from these clinically useful genomic regions.
The explosive divergence of the African cichlid adaptive radiations provides both a model for studying the general role of gene duplication in the divergence of lineages and also an exciting foray into the identification of genomic features that underlie the dramatic phenotypic and ecological diversification in this particular lineage.
The in vitro nucleosome reconstitution system comprising purified histones and genomic DNA eliminates confounding factors, thus able to capture the pure DNA features underlying nucleosome positioning.
Localizing binding elements in silico using genomic sequence analysis in conjunction with ChIP helps stratify sites and highlight relevant features underlying induction by hER.
We randomized the genomic positions of predicted recombination hotspots (n = 32,996, HapMap phase II [27]) with a rejection-sampling procedure that simulates the preferential features underlying the distribution of human recombination (Figure 3B).
TRACER data enables comparisons with the expression pattern of neighbouring genes, activity of surrounding regulatory elements or with other genomic features, revealing the underlying regulatory architecture of these loci.
The mutation rate varies within a cancer genome according to underlying genomic features such as GC content, CpG islands, and recombination rate (Greenman et al., 2007).
Liver cancer tumor specimens are difficult to obtain, and noninvasive methods are required to assess cancer progression and characterize underlying genomic features.
Results: We examine the underlying genomic features that lead to multiple alignments and investigate how they generate systematic errors in RNA-seq analysis.
