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Exploiting the local hopping activity of the Sleeping Beauty transposon, the lacZ reporter gene was dispersed throughout the Shh region to systematically map the genomic features responsible for expression activity.
Although isolates of hypervirulent CGs harbored almost no resistance genes, we did identify 2 isolates of CG23 (BG130 and BG141) that displayed genomic features responsible for high-level resistance to β-lactams, aminoglycosides, and quinolones, as confirmed by analysis of the resistance phenotype (Table S1, http://bigsdb.web.pasteur.fr/klebsiella/archives/Bialek_TechnicalAppendix.pdf).pdf
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Variation in the rate of frameshift mutations is largely due to variation in the efficiency of mismatch repair across the genome, although the genomic feature responsible for this variation is unknown.
We aimed to determine what genomic features are responsible for such unique host preferences.
These studies suggest that the migratory patterns of the virus, rather than the intrinsic genomic features, are responsible for the second pandemic wave in 2009 [ 50, 51].
In other terms, we propose to identify the genomic and transcriptomic features responsible for the "success of S. aureus" in the clinical or epidemiological settings.
Instantiating new track objects is the main way that styling information is specified, the track attributes set the final visual style of the genomic features and is responsible for placing them within the track on the page.
Thus the marks themselves, as opposed to genomic features that correlate with these marks, are responsible for targeting DNA methylation.
Comparative genomic analyses revealed several relevant genomic features of S. Cerro ST367, that may be responsible for reduced virulence of S. Cerro, including an insertion creating a premature stop codon in sopA.
Interestingly, the two pre-existing genomic features in B. napus (the A7-C6 trandlocathen A10 the A10 duplication) were responsible for the vast majority of homologous pairing disruption observed in our study, similarly to the sister population derived from self-pollination events [ 25].
Although this study identified mismatch repair as the mechanism responsible for variation of microsatellite stability, it did not identify genomic features underlying the variation in the efficiency of mismatch repair.
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