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Whole genomic expression profiling will need to be tested in other settings in breast cancer (e.g. metastatic disease, node-positive breast cancer, etc).
Genomic expression profiling has greatly improved our ability to subclassify human breast cancers according to shared molecular characteristics and clinical behavior.
In these cancers, we also correlated RAD21 expression with genomic expression profiling and gene copy-number changes and miRNAs predicted to target RAD21.
The genomic expression profiling resulted in the identification of approximately 300 genes up- and downregulated by wild-type and mutant Tax proteins.
Recent evidence supports the hypothesis that genomic expression profiling using microarray analysis is a reliable method for breast cancer classification and prognostication.
13 At the same time, new techniques in genomic expression profiling are able to characterize individual genotypes, thereby opening the door to personalized dermatologic therapy.
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In another analysis we compared our expression measure (RCBS) with the genomic expression profiles of the E. coli genome growing on rich (Luria broth glucose) and on minimal culture (glucose) medium (Supplementary Tables SVA and SVB).
GO analysis of all the genes expressed in this period revealed that the overall genomic expression profiles were very similar between ER and LL, but differences were detected in specific aspects such as cellular synapses and proteasome regulation.
VENN analysis of genomic expression profiles showed the most consistent overlap, where nearly half of the aberrantly-expressed genes from MG63 also exhibited significant changes in gene expression in U2OS cells.
But when I used bone marrow cells from treated MDS patients to develop a genomic expression profile which was startlingly predictive of response and applied for an NIH grant to validate the signature, the main criticism was that before confirming it through a prospective trial in humans, I should first reproduce it in mice!
Elegantly simple in concept, the covariation of genetic and chemosensitivity readouts provide a hypothetical link for relating compounds through genomic expression profiles to underlying biology.
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