The generated information is deciphered not only for the nucleotide sequence of the corresponding genome, but for its functional genomic expression at different conditions and states.
Gasch, A.P. et al. Genomic expression programs in the response of yeast cells to environmental changes.
Hu, G. & Agarwal, P. Human disease drug network based on genomic expression profiles.
Berry, D. B. & Gasch, A. P. Stress-activated genomic expression changes serve a preparative role for impending stress in yeast.
Gasch, A. P. et al. Genomic expression programs in the response of yeast cells to environmental changes.
Brown, Genomic expression programs in the response of yeast cells to environmental changes, Mol.
Furthermore, recent work has showed the beneficial effects of eliciting the "relaxation response" on genomic expression and oxidative stress.
Mira, N. P., Madeira, A., Moreira, A. S., Coutinho, C. P. & Sa-Correia, I. Genomic expression analysis reveals strategies of Burkholderia cenocepacia to adapt to cystic fibrosis patients' airways and antimicrobial therapy.
Elegantly simple in concept, the covariation of genetic and chemosensitivity readouts provide a hypothetical link for relating compounds through genomic expression profiles to underlying biology.
But when I used bone marrow cells from treated MDS patients to develop a genomic expression profile which was startlingly predictive of response and applied for an NIH grant to validate the signature, the main criticism was that before confirming it through a prospective trial in humans, I should first reproduce it in mice!
Comprehensive phenotypic network and pathway analysis results, which were based on genomic expression data, indicated activation of differentiation related mechanisms, via signaling pathways, including TGF, BMP, and vascular endothelial growth factor.
