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Considering the difficulty of linking complex statistical patterns to the physical structure and biological processes affecting genomic evolution, we ask whether patterns in large-scale genomic structure can be quantified using a simpler approach with an intuitive structural interpretation.
In understanding the forces driving recurrent genomic evolution, we believe that the following two axes are particularly important.
It has been suggested that low gene-gene link conservation in biological networks is due to a large numbers of non-essential (neutral) interactions [ 23]; in the same way that most fixed mutations are neutral in genomic evolution we may hypothesize that most changes to links in co-expression networks are also neutral.
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In views of genomic evolutions, we anticipated that S. oneidensis has the relics of both E. coli and Vibrio in the context of fatty acid transporter system.
We are beginning to have enough technology to reconstruct genomic evolution, but we are only beginning to realize how vastly different that is from cellular evolution.
Although many mesophilic or psychrophilic strains of Shewanella and γ-proteobacteria were sequenced for their genomes, the genomic evolution pathways for temperature adaptation were poorly understood.
This information can be utilised for comparative genomics and genomic evolution studies.
To determine hepatitis B virus genomic evolution during antiviral therapy we characterized the HBV quasi-species in a patient who did no respond to therapy following lamivudine breakthrough for a period of 14 years.
To reconstruct the genomic evolution of the 21 breast cancer genomes, we followed the approach we have described previously (Greenman et al., 2012).
To address the concerted evolution of viral genes, we compared genomic evolution across four distinct, extant viral families.
Finally, we investigated genomic evolution of white-eyes at an even finer taxonomic and temporal scale by comparing the genomes of two silvereye subspecies.
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