One of the long-standing paradoxes in genomic evolution is the observation that much of the genome is composed of repetitive DNA which has been typically regarded as superfluous to the function of the genome in generating phenotypes.
We feel that the information that can be elucidated from their genomes, in relation to the biological processes driving or constraining their genomic evolution is therefore of particular interest.
From Figure 5(a), we can see that the ratios of genomic evolution are different in different species, the maximum genomic evolution ratio is approximately equal to 0.9, and the minimum genomic evolution ratio is approximately equal to 0.6.
A better understanding of within-host genomic evolution is necessary to design effective therapies against H. pylori.
Infection can persist over many years, during which genomic evolution is driven by high rates of mutation and recombination.
This work dovetails with emerging evidence that genomic evolution is often not confined to the local genetic network thought to control the affected phenotypes.
The manuscript correctly makes clear that (i) genomic evolution is far from 100% tree-like, (ii) drawing a tree does not mean assuming that genomic evolution is 100% tree-like, and reviews the way these two basic-looking statements have been acknowledged, and their relative importance weighted, by the scientific community.
Of these two hypotheses, the gene cluster model seemed to most faithfully represent Ohno's postulate that the major mechanisms behind genomic evolution are gene duplication, modulated by mutation, insertion and deletion [ 1].
Demonstration that adoption of a parasitic lifestyle influences the rate of genomic evolution is relevant to attempts to infer molecular phylogenies of parasitic plants and to estimate their evolutionary divergence times using sequence data.
Inherent to the treatment of recurrence as a valuable and biologically meaningful tool to understand evolution is the notion that cases of repeated genomic evolution are informative if they occur in excess of the level of coincidence expected simply from the action of stochastic processes in finite sequence space.
