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The interpretation of sequence polymorphism data, such as the data produced in large amounts from genome-wide association studies, is largely based on the concept of a gene as a stand-alone, separate genomic entity with discrete start and end, as defined by the current genomic annotations.
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TEs are copious genomic entities; at least half of the human genome sequence is derived from TE insertions [ 1, 2].
The common way to separate different genomic entities in SBML is using SBO terms from the material entity branch.
These genomic entities have generally been believed to be non-functional.
WordCluster seems to predict biological meaningful clusters of DNA words (k-mers) and genomic entities.
Lung cancer that develops in the absence of significant tobacco-smoke exposure appears to be a unique disease entity with novel genomic and epigenomic alterations and activation of molecular pathways that are not generally seen in tobacco-smoke-induced lung cancer.
We present the clinico-pathological characteristics and the results of immunohistochemistry, mutation analysis, chromogenic in situ hybridization (CISH), and comparative genomic hybridization (CGH) of this rare entity with a review of the literature, providing helpful diagnostic tools in the differential diagnosis.
Comprehensive genomic and molecular characterization of GC has confirmed that EBV-GC is a distinct entity with a high CpG island methylator (CIMP) phenotype and apparent driver mutations in the PIK3CA and ARID1A genes [92], [93].
An entity with these properties is generally considered life.
The miRISC is a multipart entity with several potential members.
Sepsis is a major disease entity with important clinical implications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com