Sentence examples for genomic disruption from inspiring English sources

Originally, DNA methylation may have been evolutionarily acquired to defend against genomic disruption by parasitic insertional element translocations in eukaryotic genomes, an idea that has become widely supported (Robertson and Wolffe 2000; Slotkin and Martienssen 2007; Yoder et al. 1997).

Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute to the arrest of T cell development.

Although methods of reprogramming human somatic cells using non-viral DNA vectors have been reported [8], [9], the risk of genomic disruption may limit the therapeutic potential of these techniques.

In contrast, mice carrying a genomic disruption in the Irga6 protein coding region show no developmental abnormalities and are perfectly viable and fertile, while showing a significant susceptibility to infection with an avirulent strain of T. gondii (unpublished results and Liesenfeld, O, personal communication).

In mice, the homozygous genomic disruption of Socs1 is lethal.

The resultant hodgepodge bears little resemblance to its original structure, and the genomic disruption has wholesale and potentially oncogenic effects.

Genomic disruptions were made by long flanking homology PCR-based gene disruption.

Genomic disruptions, C-terminal tagging and promoter switches at genomic loci were performed as described previously (Longtine et al., 1998; Puig et al., 2001; Janke et al., 2004).

Genomic disruptions, insertion of C-terminal tags, and promotor switches at genomic loci were performed as previously described (Longtine et al., 1998; Puig et al., 2001; Janke et al., 2004).

Consequently, most of the genomic structural changes revealed by paired-end sequencing for this subject must be the result of poor sequencing library preparation, as it is highly unlikely that the corresponding subject can survive with such a high level of genomic disruptions.

First, we examined the liver and kidneys of mice with genomic disruptions of components of the IFN response mechanism on the C57BL/6 background [ 9] deficiencies eliminated all high Irga6 expression patches from the kidney and all Irga6 patches with mononuclear cores from the liver.