Sentence examples for genomic defects from inspiring English sources

Initially, vHMECs display a relatively stable genome; however, as the cells approach agonescence, they rapidly acquire serious genomic defects and exhibit a wildly altered karyotype typical of early cancer lesions [ 90].

Moreover, SCs could propagate their genomic defects to differentiated fibers and these defects might explain the decrease of muscle mass and response to stimuli observed in sarcopenia.

Importantly, perturbation of the ATR RASSF1A LATS1 signalling axis leads to genomic defects associated with loss of BRCA2 function and contributes to genomic instability and 'BRCA-ness' in lung cancers.

The identification of genomic defects in persons affected by morbid obesity has indicated that, at least for some individuals, the condition arises from a genetic cause.

The designs of NGS having a high depth of coverage and robust analytical pipelines can lead to the successful detection of a wide range of genomic defects in PCC/PGL.

In response to radiation, cells activate cell cycle checkpoints in G1, S and G2 phases in order to repair genomic defects, maintaining its integrity, or prevent cell division by activating cell death mechanisms (Kastan and Bartek 2004).

Another approach is more direct: engineer a genomic defect, experimentally evolve the genome to higher fitness, and observe the genetic basis of its recovery.

It gradually became clear that almost every kind of genomic defect could be found in tumor cells whether or not the mutations were connected to carcinogenesis (10, 11, 18, 26, 31).

Genetic abnormalities with chromosomal, single gene, or genomic imprinting defects account for 3.5 5 % of the causes of RM. [ 2] Other foetal defects include foetal infections and developmental abnormalities [ 3].

In this SNP-A study, we aimed at defining a cutoff value for genomic unbalanced defects influencing the median OS in a cohort of 51 higher-risk patients treated with AZA.

Moreover, it should be noted that most of the genomic instability defects demonstrated by Mcm mutations are likely the results of elongation problems (e.g., replication fork collapse); potential Mcm inhibitors that block initiation (and hence formation of the replication fork) would likely block this form of genomic instability.