Sentence examples for genomic defect from inspiring English sources

Another approach is more direct: engineer a genomic defect, experimentally evolve the genome to higher fitness, and observe the genetic basis of its recovery.

It gradually became clear that almost every kind of genomic defect could be found in tumor cells whether or not the mutations were connected to carcinogenesis (10, 11, 18, 26, 31).

Initially, vHMECs display a relatively stable genome; however, as the cells approach agonescence, they rapidly acquire serious genomic defects and exhibit a wildly altered karyotype typical of early cancer lesions [ 90].

The identification of genomic defects in persons affected by morbid obesity has indicated that, at least for some individuals, the condition arises from a genetic cause.

In response to radiation, cells activate cell cycle checkpoints in G1, S and G2 phases in order to repair genomic defects, maintaining its integrity, or prevent cell division by activating cell death mechanisms (Kastan and Bartek 2004).

The designs of NGS having a high depth of coverage and robust analytical pipelines can lead to the successful detection of a wide range of genomic defects in PCC/PGL.

Some of these measurable genomic defects may cause the lethality of Slbp null mutations.

Similar to the original assumption by de Vries et al.[16], we hypothesized that these phenotypical differences may reflect a difference in the genomic defects underlying the disorder.

Additionally, we confirmed the independence of the D341MED and D384MED cell lines; each displayed a unique allelotype and harboured distinct genomic defects [14].

Indeed, the currently accepted model of oncogenesis corresponds to a stepwise accumulation of genomic defects.

Tailored therapies, unique to the genomic defects within individual tumors, are viewed as the future of cancer therapeutics (2, 24).