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The genomic data generated from next-generation sequencing machines doesn't amount to much more than alphabet soup if it's not subjected to significant computational processing and statistical analysis.
In its simplicity, this approach provides an opportunity to truly begin integrating the vast quantity of genomic data generated in this next-generation era with clinical practice.
The volume of genomic data generated from genome-wide association studies (GWASs) is growing at an exponential rate, in large part due to the decreasing cost of high-throughput genotyping technologies.
The use of genomic data generated by so-called 'next generation sequencing' (NGS) has become commonplace in many fields of biological research, with sequencing-by-synthesis from Illumina currently the most popular.
Here, using population genomic data generated from the Hodgkinia genome project, we show that Hodgkinia has a clear AT mutational bias.
To build the genetic variations pattern of the Mongolian genome, we picked four lanes of genomic data generated from four libraries with small insert size (∼500 bp) for subsequent analyses.
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Visualization of genomic expression data, generated with human genome tilling arrays [30], shows that this particular Made1 is inserted into an intergenic region of the genome that is transcriptionally active (Figure 3).
The system is designed and widely used with genomic and data generated using high throughput technologies.
We use publically available genomic profiling data generated by the TCGA, together with data on known risk factors for kidney cancer extracted from medical records.
From the genomic sequence data generated for a placozoan (T. adhaerens), we identified and analyzed bacterial DNA sequences and compiled evidence for a rickettsial endosymbiont of T. adhaerens.
BLAST of genomic sequence data generated from PCR amplicons back to the corresponding EST allowed intron size to be estimated for each contig by subtracting the last position (3') of a query from the corresponding first position (5') of the next match.
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CEO of Professional Science Editing for Scientists @ prosciediting.com