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These results are crucial for our study because they suggest the presence of a strong genomic connection among diverse pathways associated with clinical features that seemed unrelated.
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Interestingly, the genomic connections also involve the 2 μm plasmid and the mitochondrial genome.
For example, integrative research on drug responses and genomic connections in pharmacogenomics has led to a number of identifications, measurements and evaluations of the genetic networks responsible for drug treatment at personalized level [ 45].
We believe that the GTN method will be suitable for the exploration of genomic SVs in connection with biological features of bacterial strains, and that GTN-based phylogenetic analysis will provide additional insights into whole genome-based phylogenetic analysis.
The spatial organization of genomes involves the formation of chromatin loops that bypass a wide range of genomic distances, providing a connection between enhancers and chromosomal domains.
Genome-wide details of genomic variation facilitate association of gained network knowledge with copy number variation, and abundance levels of miRNAs further provide a means to observe connections between such small RNAs, control networks and genomic variation.
To see whether there is a connection between genomic distribution of immune genes and recombination rate, I analysed spatial and recombinatorial patterns of the immunome (i.e. the genes of the immune system) of the well described and functionally characterised genome of Drosophila melanogaster.
Panzea is specific for maize, and allows an advanced Genomic Diversity and Phenotype Connection (GDPC) search.
A quantitative genetic approach involving between-population crosses would further strengthen the connection between genomic variation and adaptive phenotypic variation.
Indeed, our own results presented above do not support any connection between genomic GC content and aerobiosis.
The increasing throughput of sequencing raises growing needs for methods of sequence analysis and comparison on a genomic scale, notably, in connection with phylogenetic tree reconstruction.
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