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Another important question is that, whether different genomic components are varying together in a correlated fashion during evolution of genome size?
Our network analysis of the modules revealed that the multi-dimensional genomic components are tightly connected and the CNV, DM and microRNA can have combinatorial impact on expression of important oncogenes and tumor suppressor genes.
These genomic components are able to change the molecular composition of sex chromosomes and reduce the rate of recombination between them, which are crucial steps in the differentiation of sex chromosomes [ 30- 33].
Despite the vast DNA database that exists for higher eukaryotes, most genomic components are invisible and remain to be annotated, except for homologues of known class I and class II elements.
On the other hand, since genomic components are calculated based on the variability of the input data, it is important to generate specific sets of components for particular subsets of the data when working with structured populations.
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After WGT of Brassica ancestor, genomic components were triplicated and redundance data was generated.
Statistical approaches based on EMMAX and genomic components were tested for two different traits).
The distribution of the genomic loci in different genomic components (counting the number of tags from given components) is shown in Figure 3 and Additional file 3. The annotation of the genomic components is from UCSC.
Moreover, while using between two and four genomic components is common practice, the number of genomic components needed to control for population stratification is trait-specific (i.e. dependent on the actual genetic architecture of the trait) [ 40].
Protein-encoding and rRNA genes were all encoded on the same strand (i.e. the "+" strand), not unusual for caenogastropods, whereas tRNA genes, the most mobile mt genomic components, were distributed between the "+" and "-" strands.
Power for both EMMAX and genomic components is similar in the two tested traits, as gauged by the number of GWS signals and their significant level (Online resources 8 and 11).
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