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The micronucleus contains the complete Tetrahymena genome whereas the genomic complexity of the macronucleus (derived from the micronucleus during sexual reproduction) is reduced by ∼33% through programmed DNA elimination (http://www.broadinstitute.org/annotation/genome/Tetrahymena/MultiHome.html).html
These genomes have provided insight into the genomic complexity of cnidarians, furthering studies of gene evolution and function across basal metazoans (Poole and Weis 2014; Putnam et al. 2007; Shinzato et al. 2011; Marlow et al. 2009; Ryan et al. 2006; Hamada et al. 2013; Shinzato et al. 2012a, b; Wood-Charlson and Weis 2009; Dunn et al. 2008).
In higher income countries, there is an increasing shift toward precision medicine, where the mutational landscape is evaluated to determine the biology of the tumor, risk of recurrence, and the most appropriate treatment protocol 37. TT will need to develop a core genetics and genomics-sequencing infrastructure to address the local genomic complexity of cancer.
Thorough investigation of cALL genomes is crucial to better understand the underlying genomic complexity of this disease and thus better diagnose and treat it.
In view of the diversity of bilaterians, the genome sequence of N. vectensis has proved very informative in illuminating the genomic complexity of the Eumetazoan ancestor.
A number of recent studies have demonstrated the genomic complexity of HER2+ tumor heterogeneity, reporting that these tumors have varied and complex patterns of copy number alterations, global gene expression, and DNA methylation [ 11, 12].
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However, we expect that explicit modelling of the genomic complexities of cancer such as CNVs and subclonal populations would lead to enhanced interpretability of somatic mutation prediction and enhanced performance.
The most reliable assessment of genomic complexity in terms of gains/losses of chromosomal material was obtained by HR-CGH.
We have presented evidence of the genomic complexity and diversity of the expression of the soybean Hsp20 gene family.
In a recent paper Sharov & Gordon (SG) infer the timeline of the growth of genomic complexity in the history of life and extrapolate the trend into the past.
Four SNPs map in regions characterized by a high level of genomic complexity given the overlap of several different genes and isoforms or pseudogenes in these areas.
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