Sentence examples for genomic complexities of from inspiring English sources
However, we expect that explicit modelling of the genomic complexities of cancer such as CNVs and subclonal populations would lead to enhanced interpretability of somatic mutation prediction and enhanced performance.
The micronucleus contains the complete Tetrahymena genome whereas the genomic complexity of the macronucleus (derived from the micronucleus during sexual reproduction) is reduced by ∼33% through programmed DNA elimination (http://www.broadinstitute.org/annotation/genome/Tetrahymena/MultiHome.html).html
These genomes have provided insight into the genomic complexity of cnidarians, furthering studies of gene evolution and function across basal metazoans (Poole and Weis 2014; Putnam et al. 2007; Shinzato et al. 2011; Marlow et al. 2009; Ryan et al. 2006; Hamada et al. 2013; Shinzato et al. 2012a, b; Wood-Charlson and Weis 2009; Dunn et al. 2008).
In higher income countries, there is an increasing shift toward precision medicine, where the mutational landscape is evaluated to determine the biology of the tumor, risk of recurrence, and the most appropriate treatment protocol 37. TT will need to develop a core genetics and genomics-sequencing infrastructure to address the local genomic complexity of cancer.
Thorough investigation of cALL genomes is crucial to better understand the underlying genomic complexity of this disease and thus better diagnose and treat it.
In view of the diversity of bilaterians, the genome sequence of N. vectensis has proved very informative in illuminating the genomic complexity of the Eumetazoan ancestor.
A number of recent studies have demonstrated the genomic complexity of HER2+ tumor heterogeneity, reporting that these tumors have varied and complex patterns of copy number alterations, global gene expression, and DNA methylation [ 11, 12].
Until it does, further inquiry into the genomic complexity of the disease and advances in drug development are needed.
Improved preclinical models that more closely reflect the now recognized genomic complexity of human cancers are needed.
These findings have strong implications for understanding the genomic complexity of the earliest animals and the genetic mechanisms underlying the radiation of metazoan body plans.
