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The established cell lines also undergo genomic changes with multiple passages in culture [ 9- 11].
It is well known that smoking causes genomic changes with allelic imbalance [ 20].
If plastomic SSS exists, repeat-mediated recombination would have the potential to cause functional genomic changes with phenotypic consequences.
This could provide an alternative paradigm in cancer development, replacing the gradual accumulation of genomic changes with a "one-off" catastrophic event.
Chromosome painting is a very useful tool in phylogenetic studies because chromosome rearrangements are considered rare genomic changes with low levels of homoplasy [ 41].
Recent analyses of copy number variants (CNVs) have revealed associations of genomic changes with a variety of human diseases and disorders.
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The rearrangement of intrinsic locus structure in which thousands of copies are lost and replaced with new copies certainly represents a drastic genomic change with potential phylogenetic signal.
We were interested in applying the genome-wide analysis of rare genomic changes associated with conserved amino acids (RGC_CAs) [ 36] to date the divergence of extant eukaryotes.
We applied the genome-wide analysis of rare genomic changes associated with conserved amino acids (RGC_CAs) and used several independent techniques to obtain date estimates for the divergence of the major lineages of eukaryotes with calibration intervals for insects, land plants and vertebrates.
To identify genomic changes associated with canavanine resistance, whole genome sequencing of six independently isolated canavanine-resistant cultures was performed.
We have used a genome-wide approach to identify long-term genomic changes associated with FTP by studying breast core needle biopsies (CNBs) obtained from an ethnically homogeneous population of healthy postmenopausal volunteers residing in Norrbotten County, Sweden.
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