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To gain insight into the genomic changes underlying the emergence of virulence, we sequenced the genomes of these two, and three other non-pathogenic Nakaseomyces, and compared them to other sequenced yeasts.
In addition, in cultivated bacteria there are usually many mutations between strains, so that precise genomic changes underlying chemical variation cannot be readily determined.
Recent array-CGH analyses have shed further light on the genomic changes underlying the neoplastic development of UC, and have facilitated the molecular delineation amplified and deleted regions to the level of specific candidate genes.
Indeed, unlike the relatively small proportion of cancers that are hereditary and for which germline genetic testing is relevant, molecular oncology testing for the acquired genomic changes underlying sporadic cancer is potentially relevant to all forms of malignancy.
Recent array CGH analyses of bladder tumors [ 6, 7] and cell lines [ 8], based on non-tiling bacterial artificial chromosome (BAC) arrays have shed further light on the genomic changes underlying neoplastic development.
Despite the well-characterized selective environments and phenotypic variation in this system, there are currently no genomic resources to start addressing questions about the genomic changes underlying trait divergence.
Similar(54)
What genomic changes underlie trends in gametophyte reduction and the shift from haploid-dominant to diploid-dominant life cycles across land plants?
Given that genomic changes underlie the cancer phenotype, DNA copy number amplification is a justified foundation for classification.
The identification of genomic regions that have been affected by positive selection in humans, but not in other primates, is a promising avenue for characterizing the genetic changes underlying phenotypic traits that are unique to humans.
What is the nature of the genetic changes underlying adaptation?
Such a finding would be of particular importance for studies of human evolution, where, despite intensive effort, the identification of genomic or mRNA expression changes underlying human-specific phenotypic features has been a daunting and hitherto largely elusive task [13], [14].
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