Our studies have examined hyperplasia, DCIS and IBC from cross-sectional samples, by both targeted sequencing [ 12] and whole genome sequencing [ 10], to identify genomic changes that occur in progression from these pathologically defined neoplasias.
A comprehensive inventory of putative orthologs, orphan genes, and lineage specific gene expansions coupled with functional genomics data will provide important insights into genomic changes that led to the adaptive radiation of crustaceans.
The Cancer Genome Atlas (TCGA) is a large-scale collaborative effort to systematically characterize the genomic changes that occur in cancer by applying genome analysis technologies.
The whole-genome resequencing data generated on this study shed light on the genomic changes that have accompanied this evolutionary response.
The circadian oscillator is astonishingly robust to changes in the environment but also to genomic changes that alter the copy number of its components through genome duplication, gene duplication, and homeologous gene loss.
An important consideration therefore is not the genomic changes that cause an increased frequency of plastome reorganization, but what genome changes allow such major plastome changes to persist without being eliminated as deleterious.
Genome scans between incompletely reproductively isolated populations and species offer snapshots of the genomic changes that accumulate during the speciation process.
A recent study involving whole genome sequencing of seven prostate cancers has provided the first comprehensive assessment of genomic changes that underlie this common malignancy.
We constructed the reference genome of bezoar and sequenced representative breeds of domestic goats to search for genomic changes that likely have accompanied goat domestication and breed formation.
However, immortalisation often disrupts cell cycle regulatory mechanisms, or results in epigenetic or genomic changes that allow cells to escape quiescence [7].
In order to get insights into the genomic changes that may be associated with invasiveness, we undertook the sequencing of Z5463 and its two derivatives Z5463PI and Z5463BC.
