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These global genomic changes are mostly induced and facilitated by reactivated mobile genome elements [ 15] through relaxation of epigenetic mechanisms, such as repressive covalent modifications to DNA and histone proteins which normally keep them in the silent heterochromatic state [ 16, 17].
These genomic changes are cryptic, but are always found within the Enterobacteriaceae flexible genome.
Many of these genomic changes are thought to represent driver mutations in oncogenesis.
The genomic changes are not distributed uniformly at random.
Genomic changes are less well characterized.
In conclusion, gene expression values in regions with genomic changes are altered in the same direction.
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The extent of genomic changes was defined as the fraction of the genome altered (FGA), as described by Blaveri et al (2005).
A number of studies suggest that the pattern of DNA-based genomic changes is prognostic in neuroblastoma, and that whole genome analysis should be carried out rather than a series of individual locus-specific assays.
Although the mechanisms driving such change remain unclear, these results provide a compelling example of a broad syndrome of genomic changes being driven by apparently nonadaptive events, while also demonstrating that mammalian genome architecture is currently in a nonequilibrium state.
We argue that internal genomic changes were as important as external factors in the emergence of animals.
The rapidity by which the landscape of mutation and genomic changes is being identified also has led to a new paradigm and approaches to pathological diagnosis of NSCLC.
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