Sentence examples for genomic binding to from inspiring English sources

We then compared these Eomesa-responsive genes to Eomesa and Smad2 genomic binding to identify functional binding.

To investigate the relevance of these interactions for the ESC transcriptional network, we tested the effect of acute Oct4 depletion by 12 hr doxycycline treatment, on the recruitment of Dax1, Tcfcp2l1, and Esrrb to a number of genomic binding sites to which Oct4 also binds (Chen et al., 2008b; Kim et al., 2008).

At other genomic regions, binding to the ETS domain may be preferred by one factor over another, particularly at combined ETS-IRF elements where Spi-B is the principal partner for recruiting IRF4 to regulatory regions [ 10].

Most published accounts of genomic binding site searches to date have leveraged sequence conservation with great success.

TF are highly context-specific, and the same TF typically binds to different genomic binding sites in different conditions.

Genome-wide profiling by ChIP-Seq has made it possible to map genomic binding sites of these factors and to distinguish direct vs. indirect regulators of PPARγ expression during adipogenesis in an unbiased way.

In light of our finding that RUNX1/3 and ETS1 are important for mediating TAL1 genomic binding, it is interesting to note that TAL1 also appears to directly regulate the expression and function of RUNX and ETS proteins, which suggests a multipronged mechanism for TAL1-mediated leukaemogenesis.

PKA isoforms change their genomic binding sites from ORF to promoter regions during yeast-hyphal morphogenesis.

Functional relationships between GR and its targets are often classified as "direct", that involve GR recruitment to genomic binding sites associated with regulated genes, and "indirect", whereby primary GR-regulated factors, rather than GR itself, are responsible for activation of the downstream targets.

Fastq files were downloaded from GEO (accession number GSE44672) and were aligned to the human genome (hg19) using bowtie 2. We used Cisgenome [ 59] to detect genomic binding sites bound by Myc.

Systematic efforts to determine genomic binding sites, the identity of co-binding transcription regulators and associated histone marks to reveal the predominant mechanisms of action including the often overlooked transcriptional repression are also needed.