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These studies collectively demonstrate the power of applying a genomic approach based on global gene expression to identify genes that may be involved in common pathways giving rise to ASD.
We devised a comparative genomic approach based on sequence conservation to identify regulatory elements that could mediate activity-dependent transcription of the miR379 410 cluster.
To better define the cellular machinery associated to this condition, we employed a high-throughput genomic approach based on a whole transcriptomic analysis associated with classical molecular methodologies.
Global gene expression is a functional genomic approach based on data derived from DNA microarray technology and analyzed by bioinformatics tools [ 11].
In this study, gene expression profiles obtained by genomic approach based on DNA microarray analysis shed light on the new molecular mechanism of SWT.
We recently reported a clinical triad classification system using a genomic approach based on the common gene expression pattern of human epidermal growth factor receptor 2 (HER2) positive and triple negative (HER2+/TN) breast cancers.
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The observation that the function of an enhancer, rather than its sequence, may be the main factor under selection suggests that related species have the potential to share many enhancers of similar function but divergent sequence; this type of enhancers would be invisible to genomic approaches based on sequence conservation.
Reverse-genetic and/or post-genomic approaches based on nucleotide sequence information are therefore vital for such investigations.
In this study, we aimed to develop a system biology approach based on genomic convergence of genetic data from multiple high-dimensional genome-wide studies and network modelling of protein-protein interactions to prioritize candidate genes linked to AD.
These results indicate our phylogenetic approach based on genomic abundance is robust against uneven sampling of proteomes in superkingdoms.
Here, we report on a resolution statistic for genomic microarrays that uses an approach based on hypothesis testing and statistical power calculations.
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