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Using a combination of genetic mapping, whole genome sequencing, and genomic analysis, we have identified and confirmed several genomic lesions linked to MMC-induced DNA damage in Caenorhabditis elegans.
Using comparative genomic analysis, we compared the genomes of three host-adapted groups of strains from the phylotype II of R. solanacearum: brown rot strains adapted to potatoes and temperate climates, Moko strains adapted to bananas, and NPB strains adapted to melon or Anthurium.
Based on comparative genomic analysis, we found that vertebrate TRAF6 exhibits two distinct structures in teleost and tetrapod lineages.
In an attempt to perform comparative genomic analysis, we compared genes mapped from our EST database to human, mouse, rat, and bovine using NCBI's HomoloGene database.
During our genomic analysis we found HRV A2 strains shared only 50% 53% average amino acid sequence identity with other HRV strains (Figure 1); less with any strain from an HEV species.
Using high throughput genomic analysis, we have found that Ets-1 regulates, either directly or indirectly, several important genes involved in mitochondrial metabolic and antioxidant defense pathways in our Ets-1 over-expression ovarian cancer cell model.
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From this first step of post-genomic analysis, we obtained relevant information for future technological development.
From this first step of post-genomic analysis, we obtained information relevant to future new drug development.
In this paper, we have shown the detailed genomic analysis that we used for the initial annotation of these proteins.
This property is important for genomic analysis, because we usually need to calculate small P-values to correct large-scale multiple hypothesis testing.
In order to assess linearity in each genomic analysis assay, we plotted the log2ratio values of the subset of 28 genes validated by RT-PCR and found that DGE approximated best the fold change detected by RT-PCR.
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