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The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers.
Molecular oncology testing (MOT) to detect genomic alterations underlying cancer holds promise for improved cancer care.
Personalized or 'targeted' oncology is made possible by scientific developments identifying the genetic and genomic alterations underlying cancer.
Clinical molecular oncology testing (MOT) for the acquired genomic alterations underlying sporadic cancer has an increasingly important role to play in the diagnosis and treatment of cancer.
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Based on the observation that frequent genomic alterations underlie a more aggressive cancer phenotype, we asked if such an effect could be detectable as an increase in the randomness of local gene expression patterns.
In the past, loss of heterozygosity (LOH) [ 32], fluorescence in situ hybridization [ 33], and chromosomal comparative genomic hybridization (CGH) [ 34] were techniques used to identify the genetic alterations underlying solid human neoplasms.
A key goal in cancer research is to find the genomic alterations that underlie malignant cells.
Whole genome sequencing (WGS) has allowed an unprecedented insight into the alterations underlying cancer.
However, somatic alterations underlying these phenomena remain unexplained.
The pathophysiological alterations underlying SAE are incompletely understood.
The biological alterations underlying this pattern remain unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com