genomic alteration

USAGE SUMMARY

The phrase "genomic alteration" is correct and usable in written English.
It can be used in contexts related to genetics, biology, or medical research when discussing changes or modifications in an organism's genome. Example: "Recent studies have shown that genomic alteration can lead to significant changes in an organism's traits and behaviors."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

Genomic alteration has been shown to confer altered capacity for cell proliferation, metastasis, and responsiveness to either normal cellular signals or therapeutic agents [ 1].

Breast Cancer Research

The proposed score is based on two items: (i) the overall level of genomic alteration (noted A) and (ii) the number of altered genomic regions (noted N).

BMC Medical Genomics

After all, constructing a drive to spread a particular genomic alteration in a given species was simply not feasible with earlier genome editing methods.

eLife

Essentially, the novelty of CRISPR gene drives is the ability to spread any type of genomic alteration through entire wild populations and ecosystems.

The Guardian

It was apparent that K209 had a genomic alteration in the molecular mechanism responsible for Pb1-mediated resistance gene activation.

Rice

Approximately half of prostate cancers carry TMPRSS2-ERG translocations; however, the clinical impact of this genomic alteration remains unclear.

Clinical and Translational Medicine

Statistical approaches for analyzing copy number data are aimed at detecting the regions of genomic alteration.

Plosone

The identification of regions of genomic alteration enriched in primary or metastatic melanoma is discussed below.

Plosone

Our analysis found no evidence of genomic alteration of the RUNX1 gene.

Plosone

In the five patients studied here, no other genomic alteration was consistently detected in the ICCA area.

Plosone

This includes the most common genomic alteration, a deletion of 13q14.2 q14.3 including the RB1 tumor suppressor (∼60% of tumors).

Plosone

Expert writing Tips

Best practice

In scientific articles, clearly specify the type of "genomic alteration" you're referencing (e.g., mutation, deletion, insertion) for better clarity.

Common error

While "genomic alteration" is technically correct for any change in the genome, it is best used in scientific or technical contexts. For general audiences, consider using terms like "genetic change" or "DNA variation" for better understanding.

Linguistic Context

The phrase "genomic alteration" functions primarily as a noun phrase. It serves to identify and categorize changes within the genome of an organism, as showcased by Ludwig's examples.

Expression frequency: Very common

Frequent in

Science

88%

News & Media

10%

Formal & Business

2%

Less common in

Academia

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

In summary, "genomic alteration" is a frequently used and grammatically correct noun phrase referring to changes in an organism's genome. Ludwig's analysis of numerous examples demonstrates its prevalence in scientific and medical research. The term, as highlighted by Ludwig, is best suited for formal and technical contexts, while simpler alternatives such as "genetic change" might be more appropriate for general audiences. While often used to describe undesirable changes that can occur in genes (e.g. cancerous mutations), the usage of this term can have a broader meaning.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

genomic change

A more general term for any kind of change in the genome.

genetic modification

Focuses specifically on changes introduced intentionally to the genetic material.

genomic mutation

Implies a spontaneous change in the genome, often with negative connotations.

chromosomal aberration

Refers specifically to abnormalities in chromosome structure or number.

dna variation

Highlights the differences in DNA sequences within a population or between individuals.

genome editing

Describes the process of precisely altering DNA sequences in a targeted manner.

genetic anomaly

Suggests a deviation from the norm in an organism's genetic makeup.

inherited alteration

Highlights a change passed down through generations.

genomic instability

Describes a condition where the genome is prone to frequent changes or rearrangements.

epigenetic modification

Involves changes in gene expression without altering the DNA sequence itself.

FAQs

How is "genomic alteration" different from "genetic mutation"?

"Genomic alteration" is a broader term encompassing any change to the genome, while "genetic mutation" typically refers to spontaneous changes in DNA sequence that may have functional consequences. A "genetic mutation" is a specific type of genomic alteration.

What are some common types of genomic alterations?

Common types of genomic alterations include point mutations, insertions, deletions, copy number variations, translocations, and inversions. These can affect gene expression, protein function, and ultimately, cellular behavior.

In what contexts is it appropriate to use the phrase "genomic alteration"?

The phrase "genomic alteration" is most appropriate in scientific, medical, and research contexts when discussing changes to the genome, particularly in relation to diseases like cancer or inherited disorders. It's less common in general conversation.

What can I say instead of "genomic alteration"?

Depending on the context, you could use phrases such as "genetic modification", "genomic change", or "DNA variation". The best alternative depends on the specific meaning you want to convey.