Sentence examples for genomic activation from inspiring English sources

This has also an important impact at the time of genomic activation, the longest cell cycle of preimplantation development.

The AR expressed in the stable WPMY-AR cells was functional for genomic activation of gene expression.

The altered expression of CCNA1 is similar to the expression of EIF1AX, another marker for zygotic genomic activation in our study as well as in a previous animal study [32].

The altered expression patterns of Cyclin A1 (CCNA1) in parthenotes changed from high (in morula) to low (in BLs) compared to IVF/ICSI embryos, which may due to it inefficient zygote genomic activation [31].

Such PTM crosstalk has the potential to act as a completely new level of cellular regulation, allowing rapid changes in function without the requirement for genomic activation.

However, these methods demonstrated that xenoestrogens act very weakly (only at concentrations 1,000- to 10,000-fold higher than E2), if at all, via genomic activation pathways.

Remarkably, the non-genomic activation of PAK-1 by estradiol controls hormone negative feedback actions in the reproductive axis in vivo [15].

Increasing evidence has shown that non-genomic activation of the ERK1/2 by estrogen in both breast and endometrial cancer cells [44], [45], [46].

pERK protein was earlier detected in association with ERα and MS-KIF18A, suggesting a role for the MS-KIF18A in non-genomic activation of ERα through the MAPK pathway [12].

Emerging evidence also implicates estrogens in the rapid, non-genomic activation of PI3K via IGF-1R/insulin receptor (InsR), EGFR, Src, PI3K, and MEK [ 53- 56].

In breast cancer cells, ERα can mediate genomic transcription regulation with nuclear initiated steroid signalling and non-genomic activation of various protein kinase cascades [ 11].