The genomic action of 1,25(OH)2D3 is mediated by binding of VDR-retinoid × receptor (RXR) complex at the vitamin D response elements on target genes.
In this effect no genomic action of TZDs was involved.
The non-genomic action of progesterone on [Ca2+]i in human sperm has a biphasic dose effect relationship, apparently reflecting effects at high- and low-affinity receptors [ 12, 38].
The effects of testosterone on muscle and bone involve protein synthesis and are a result of genomic actions of testosterone and, therefore, rather slow.
In the present study we investigated the effects of Pred on broader aspects of platelet functions to unveil novel non-genomic actions on this cell type.
Several studies have focused on the likely genomic effects of p, p′-DDE on male fertility (You et al., 1998; Loeffler and Peterson, 1999; Ayotte et al., 2001; Hauser et al., 2002, 2003; Rignell-Hydbom et al., 2005a, 2005b; De Jager et al., 2006; Toft et al., 2006; Stronati et al., 2006; Aneck-Hahn et al., 2007), without exploring possible rapid non-genomic actions on human sperm.
Regardless, the rapid non-genomic action of GCs has been extensively reported in the CNS [ 14], and this action is biologically relevant, as Zhou et al previously demonstrated the rapid non-genomic effects of GCs on allergic asthmatic reactions in the guinea pig [ 17].
Given the, sometimes conflicting, results on PPARδ biology obtained using various pharmacological and molecular genetic tools we set out to study the ligand modulated antagonism of PPARγ1 by genomic and non-genomic actions of PPARδ.
On the other hand, a few reports have now demonstrated that AR can be recruited in non-genomic actions of androgens (reviewed in Hammes and Levin, 2011).
Therefore, ERs may participate in both the genomic (transcriptional) and non-genomic actions of E2 [ 2].
