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The three remaining CNV regions are completely devoid of coding sequences, but using the Evolutionary Conservation of Genomes Browser [57] we identified conserved segments that might have some potential biological function that has not yet been uncovered (data not shown).
To date, the 1000 genomes browser provides high-coverage sequencing data and alignments for one mother-father-child family of the European ancestry from Utah, U.S.A. and the other family trio of the Yoruba ancestry from Ibadan, Nigeria.
For the eight non-frameshift introns generated by intronization, we examined whether they are under natural selection by checking their genetic variation in different human populations with the 1000 Genomes Browser [ 46].
To our knowledge, this mutation had not been reported before; in addition, it was absent in the database of pathogenic mutations Human Gene Mutation Database-HGMD (http://www.hgmd.cf.ac.uk/ac/index.php/) and was neither reported in the Exome Variant Server (http://evs.gs.washington.edu/EVS/), nor in the 1000 genomes browser (http://browser.1000genomes.org/index.html).html
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To identify evolutionary conserved regions (ECRs), comparative genomics was performed using the ECR genome browser (http://ecrbrowser.dcode.org/) (37) and the University of California Santa Cruz genome browser (http://genome.ucsc.edu/).ucsc.edu/
Fig. S2 Genomic region surrounding rs2075650 (obtained from the UCSC genome browser (http://genome.ucsc.edu/).ucsc.edu/
The sequence and genomic organization were obtained from the University of California Santa Cruz (UCSC) genome browser (http://genome.ucsc.edu/).ucsc.edu/
When we began considering the implementation of a genome browser at MaizeGDB, various other resources already represented maize genomic sequence visually via genome browsers.
The genomic ADAR2 human and mouse sequences were analyzed using the UCSC genome browser [22].
Genomic locations of B.mori FMOs were determined by using the gbrowse genome browser of Kaikobase.
Three of the most popular genome browsers employed to visualize cancer alterations are the Integrative Genomics Viewer (IGV) [ 20], the UCSC Cancer Genomics Browser [ 21], and the Savant Genome Browser [ 22].
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