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Because reliance on isolate genomes alone limits the scope of observable genomic heterogeneity, recent efforts have focused on using random shotgun sequencing of microbial communities followed by assembly and documentation of various types of within-population variability.
Despite the declining cost of 'personal genomes' and the acknowledged usefulness of individual genome sequences to understand human health, for the near future, personal genomes alone are unlikely to become the leading research tool in genomic medicine.
The sequencing of genomes alone is not a panacea.
The sequence complexity of the known vertebrate genomes alone is insufficient to account for the diversity between individuals of a species.
If scientists are trying to find fungi or bacteria that can perform a specific job – say, clean up hazardous waste, to produce certain nutrients – it would be valuable to identify such organisms from their genomes alone.
Comparative analysis of the three R. felis genomes alone was carried out to identify a core genome and determine the composition of the accessory genome.
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The current Wm82_v2 reference genome alone cannot provide conclusive answers to questions regarding large structural variations and complex genomic rearrangement.
Similarly, the effects of environmental factors or multigenic processes such as ageing or disease cannot be assessed simply by examination of the genome alone.
Classical zinc fingers are extremely versatile, as can be seen by their abundance in nature: over 700 proteins contain such domains in the human genome alone, making them the second most common human protein motif.
Umbel's Digital Genome alone collects, analyzes and visualizes 18,446,744,073,709,600,000 data points per person in less than one second.
In fact such acquisition would be less likely than upon administration of the standard genome alone.
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