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MicroRNAs are 20 22 nucleotide long non-coding RNAs encoded by eukaryotic genomes, act as one of the key regulators of post transcriptional gene regulation [ 116].
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Nearly all RVFV particles should contain genome since encapsidated genome acts as the stimulus for virion formation.
Utilizing a Rift Valley fever virus-like particle (RVF-VLP) system, we have determined that encapsidated genome acts as the primary stimulus for RVFV release from the cell.
In the case of human mitochondria, the model of replication where each genome acts as an individual unit and replicates independently, even while being part of a focus appears as the one most satisfying the observed kinetics.
Therefore, it can be extended to the analysis of Hi-C data [ 18], where every restriction fragment in the genome acts as a viewpoint (Mukhopadhyay S. et al., in preparation).
During these processes, the ssRNA viral genome acts as a template for: (1) the synthesis of the intermediate ssRNA strand by the NS5 RdRp, which in turn acts as template solely for the synthesis of ssRNA genomic RNAs (again by the NS5), and (2) the synthesis of the viral polyprotein.
The presence of large genomes in the solution set suggests that large, versatile genomes may act as hubs in the global LGT network [ 55], since so many of the genes they possess can be adaptive in different environments.
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Found in all animal and plant cells, as well as in viral genomes, miRNAs act as inhibitors of protein translation by binding to a short six-nucleotide region within the 3′-untranslated region (3′-UTR) of their target mRNAs (Bartel 2004; Bartel and Chen 2004).
These genomes can act as controls for mutation significance in rare Mendelian disorders in which previous studies were often limited to sequencing a few hundred controls to determine if a detected variant is rare and normal or unique to a syndrome.
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