Exact(2)
Recent studies have found that aberrant events, including chromosomal rearrangements in the target cell genome, were induced by the ΦC31 and R4 integrases [49], [50], [51], [52].
For the amplification of the genomic HCV RNA strand, two sets of oligonucleotide primers (Bio-Synthesis, USA) deduced from the highly conserved 5′-noncoding 5′-noncodingV genome weregionuced in the first and secofd stage, respectively.
Similar(58)
Only one of the five groEL genes in MAFF303099 genome was induced by heat shock.
RAG-induced DSBs are tightly regulated and only a small number of breaks in very specific locations in the genome are induced.
Next, membrane fusion of the viral envelope with the endosomal membrane is induced by the conformational change of HA, and the viral genome is induced into the cytoplasm of host cells.
Mutational studies showed that groESL operons within the same genome are induced by different stimuli and that these genes are involved not only in stress tolerance, but also in the nodulation and nitrogen fixation processes.
We also provide an implementation of the Composite Repeat Induced Point mutation index (CRI), a dinucleotide frequency distribution analysis tool for evaluating the likelihood that DNA methylation in a given genome is induced by "Repeat-Induced Point mutation" (RIP) [ 12] (see "Availability and requirements of Software Used" for details).
Corresponding to the one insertion mutation in promoter, one ldh (Teth5140216; the only ldh in X514 genome) was induced, whereas solvent formation genes were inhibited that included butyrate kinase (Teth5140936), phosphate butyryltransferase (Teth5140937), and iron-containing adh and its associated NADH oxidase (Teth5140145-0146) (Additional file 15A).
For example, many low copy repeats (LCRs) in mammalian genomes are induced by segmental duplications [ 10].
However, it is unknown whether changes in methylation profile of cellular genomes are induced by insertion of adenoviral DNA or just by insertion of any foreign DNA (Doerfler 2009).
In this study, we utilized zebrafish as an in vivo model to study DSB repair and demonstrated that efficient MMEJ repair occurred in the zebrafish genome when DSBs were induced using TALEN (transcription activator-like effector nuclease) or CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 technologies.
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