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Dispensable chromosomes that determine pathogenicity in various species can be seen as the most extreme case of genome structuring.
In our model, we observe dynamic patterns of genome structuring that operate on different evolutionary timescales.
Repetitive sequences play essential roles in genome structuring and evolution, and they usually expand disproportionally to genome enlargement[ 38].
More specifically, genome structuring and evolutionary adaptation in a population of cells to a fluctuating environment feed back on each other to accommodate robustness to ongoing mutations as well as evolvability in terms of genetic variability on a population level.
In our virtual cell model, which exhibits a high degree of flexibility in the evolving genotype to phenotype mapping, it proved crucial to analyze the interplay between adaptive and neutral evolutionary processes in detail in order to understand the evolutionary dynamics of genome structuring and the evolutionary potential of the different lineages.
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Genomes structured in operons have fewer target sites for deleterious mutations in regulatory regions.
The generated genome structure ("genomeMap.mrc") serves as structural model for next round of orientation determination of the genome images.
Cnidaria mtDNA displays variations not only in the genome structure but also in genomic components.
This protocol is also applicable for the genome structure determination of other icosahedral viruses with structurally homogenous genomes.
Genomic resources have been recently developed to study the genome structure of Musa species.
The genome structure of R. sativus was reconstructed by these genomic blocks (Fig. 2).
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