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This suggests that genome sequence variations between founders had a large and immediate impact on the expression of these genes.
Another issue is that information about mobile elements of the genome is removed from or ignored in the datasets compiled from many phylogenetic studies of genome sequence variations.
To improve the ability to detect SARS-CoV safely and reduce the risk of eliciting false-negative results caused by genome sequence variations, we established three individual real-time RT-PCR assays.
Despite that HPV genome is viewed as a stable genome, its genome sequence variations in a given genotype appear different from one laboratory to another and from one geological region to another [ 14- 22].
Although genetic regulation is always a factor in gene expression, for these genes, expression differences between founder strains may be more directly explained by genome sequence variations within or near those genes.
Both ERG8 and ERG9 were not significantly differentially expressed, either in glucose or galactose, suggestive again that phenotypic observations, consistent with genome sequence variations, are not necessarily directly manifested at the transcriptome level.
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Schaffner, S.F. et al. Calibrating a coalescent simulation of human genome sequence variation.
He is deeply interested in mapping both coding and non-coding genome sequence variation to phenotype differences, and in extracting specific genetic insights from high throughput sequencing measurements, in the contexts of development and developmental abnormalities.
The rapid development of molecular genetic technologies allows highly detailed examination of genome sequence variation and leads to rapid progress in the understanding of the genetic architecture of complex diseases.
Molecular genetic maps provide a means to link heritable traits with underlying genome sequence variation.
In contrast to B. mallei, there is little genome sequence variation among the B. anthracis isolates (reviewed in [ 37]).
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