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Biological responses are consequence of the concerted action of gene regulatory network, thus, limiting our attention to genes having the most significant variations is insufficient for a thorough understanding of emergent whole genome response.
Building upon the accuracy and reliability of a correlation metrics based upon thousands of statistical units (genes, ORFs), we investigated temporal whole genome response to LPS stimulation in the above-mentioned 4 different genotypes of macrophages.
In mouse embryonic fibroblasts the whole genome response to growth hormone has been investigated using STAT5 as a marker [ 22].
Functional analysis of these genes was done to relate the genome response to the shift in biological activities.
West African cattle populations thus represent an appealing model to unravel the genome response to adaptation to tropical conditions.
The genome response to syringaldehyde challenge was similar and very closely related to the non-treated control.
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Since the parental materials were strictly inbred over many years, any genomic changes revealed in the triticale should be directly related to genome responses to polyploidization.
Overall, these results suggest that whole genome responses possess fractal-like nature for neutrophil differentiation.
Genome responses include elevated rates of homologous recombination that persist for multiple generations, changes in copy number and modulation of epigenetic gene regulation.
In this study, we investigated genome responses to ultraviolet and γ-radiation and accumulation patterns of UBF1 and HP1β at UVA-damaged chromatin in live cells.
In addition to the genome responses listed above, our findings suggest that an intrinsic source of genetic variation can be leveraged to enhance the diversity in genetic output achieved by Arabidopsis plants.
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