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Interestingly the covariation for shape for the IRCSs carrying the highest SEG genome rate affected all parts of the mandible.
Moreover, the shape changes for the IRCSs carrying the highest SEG genome rate (120C, 122D, 6C, 5A, and 49A) in our dataset were widespread throughout the mandible.
Previous attempts to place At-β were clearly confounded by nuclear genome rate heterogeneity (Tang, Wang et al. 2008), and our rate-standardized analyses reconcile the previously conflicting data on At-β.
Remarkably, these data also demonstrated that the accumulation of the SEG genome rate in this set of IRCSs increases the magnitude of the QTL effects in an additive, but not in a modular pattern, manner.
Calculating U, the diploid genome rate of detrimental mutation per generation, from these values is not straightforward: a per locus mutation rate does not easily transform into a per genome detrimental mutation rate [ 35].
Interestingly, shape differences for the congenic strains (135E, 137E, and 157D) and the IRCSs carrying the highest SEG genome rate (120C, 122D, 6C, 5A, and 49A) were localized on the mandible as a whole.
Similar(53)
This disagreement is likely driven by multiple factors, such as microsatellite birth/death rate variation along mammalian genomes, rate variation accross the tree of mammals, and differences in estimation methodologies employed in the two studies.
Interestingly, this correlation between molecular evolution rates and genome rearrangement rates has been found at the interspecific level in animal mt genomes (Xu et al. 2006).
If both hosts have allele m, the (per genome) recombination rate is r mm (i.e. the wildtype recombination rate).
But compared to Drosophila simulans, we found a similar phenomenon of a nuclear genome mutation rate (1.8 × 10-2) [ 38] being higher than the mitochondrial rate (1.1 × 10-3) [ 8].
The spontaneous genome mutation rate (μg) of Thermoanaerobacter sp. X514, calculated at 0.045, suggested a higher mutation rate in thermophile than previously thought.
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