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Therefore, these results strongly indicate that the method applied here, i.e., random PCR-based genome profiling, could provide the sufficient amount of genomic information from a single cell.
High-throughput genome profiling for genetic marker discovery is widely applied in the field of genomic and personalized medicine.
Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others.
In only a few reports have such whole genome profiling efforts been integrated [14], [15], allowing a multi-dimensional characterization of biological systems [16].
Our results here indicate that whole genome profiling is certainly not necessary as we obtain very reasonable predictive accuracy, sensitivity and specificity with 150, 100 and 50 total genes per signature.
DNA microarrays provide an unprecedented capacity for whole genome profiling.
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Complementary to assaying single loci for MAS, whole-genome profiling can be utilized for genomic section, QTL mapping, and diversity analysis [ 11].
Advances in technology allow for whole-genome profiling, which cancer researchers are currently using to identify molecular profiles found in chemotherapy-resistant ovarian cancer.
The MDV software could be particularly helpful to other biofilm-related fields using whole-genome profiling for comparison of multiple experimental conditions, such as comparative-transcriptome of distinct strains or in response to therapeutic agents.
Methylation has been primarily considered as a mechanism of tumor suppressor gene (TSG) inactivation, and comprehensive whole-genome profiling approaches to promoter hypermethylation have identified multiple novel putative TSGs silenced by promoter hypermethylation.
Additional file 1: BAC fingerprinting by whole-genome profiling.
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