Sentence examples for genome problematic from inspiring English sources

This degeneracy of functional AREs, and also the divergence from the in vitro-derived binding sequence, make computational prediction of AR-binding sites in the human genome problematic.

However, RNA-DNA mismatches between RNA-seq reads and the genome make the alignment of nucleotide variations to the genome problematic.

The mutually exclusive nature of the two regions makes epistatic analysis of loci involving these regions of the genomes problematic.

This lack of periodicities, diagnostic of the presence of a nucleosome positioning signal, makes the extraction of a nucleosome signal from such "silent" genomes problematic.

However, the relative short read length makes genome assembly problematic and their use in bacterial genomics has been fairly restricted to new strains closely related to already sequenced organisms to identify for example virulence factors [9], antibiotic resistance genes [10], or epidemiological markers [11].

However, the identification and characterization of highly homologous sequences in the genome remain problematic.

This sequence relatedness makes it difficult to precisely assign individual gene fragments or transcripts to their subgenome of origin, and in turn makes determination of an accurate bread wheat reference genome sequence problematic.

Zhao et al. [ 11] show that poor sequence coverage can be overcome by using multiple reference genomes, but problematic for this approach are major rearrangements in the genomic sequences of more distantly related species.

Rooting the phylogeny using divergence from other ebolavirus genomes is problematic (Fig. 2A and fig. S6) (6, 13).

Correct annotation of these genomes remains problematic despite gene prediction algorithms becoming ever more sophisticated.

The analysis of polyploid genomes is problematic because homeologous subgenome sequences are closely related.