Sentence examples for genome modifications from inspiring English sources
Furthermore, the zebrafish model offers a plethora of molecular-genetic techniques and bioinformatics tools, including methods for transgenesis, mutagenesis, gene knockdown, and targeted genome modifications, together with advanced genomic annotation.
To investigate the successful genome modifications of the F0 founder line, the genomic region surrounding the TALEN target was amplified and subcloned.
They create DSBs at specific genomic loci, promoting homologous recombination, and efficiently increase the frequencies of induced genome modifications (Gaj et al., 2013).
Current methods for making synthetic interspecies hybrids are cumbersome and/or require genome modifications.
These features considerably expand the options for systematic, stepwise genome modifications.
Therefore tools and methods for targeted genome modifications are of great interest.
Programmable nucleases have revolutionized zebrafish genetics by enabling targeted genome modifications.
Epigenomics methods are being developed to catalogue genome modifications under normal and pathological conditions.
Thus, they provide a valuable approach to targeted genome modifications such as mutations, insertions, replacements or chromosome rearrangements.
The resulting DNA double strand break activates cellular repair pathways that can be harnessed for targeted genome modifications.
We also discuss future directions in sgRNA/Cas9 applications for generating targeted genome modifications and gene regulations in plants.
