Exact(5)
Third, do additional factors such as variation within the repeat expansion, variation in local gene expression, or modifiers elsewhere in the genome influence the disease?
It is believed that the species and number of tRNAs in the genome influence the compositional bias for codon selection [ 30].
This fits perfectly with the notion that many particularly C + G rich elements (including CpG islands) across the genome influence the efficiency of analysis of surrounding contiguous sequences by severely hindering DNA denaturation.
Previous studies by Ballard and co-workers have provided empirical evidence that variation in the mitochondrial genome influence multiple aspects of respiration in wild-caught D. simulans flies [ 28, 29].
It is well appreciated that characteristics of the reference genome influence this mapping step; for example, some sequences in the genome are present in multiple copies, leading to ambiguity when determining the origin of a sequencing read (Koehler et al., 2011).
Similar(55)
Concepts, experience, and tools from metabolic engineering are immediately applicable to the challenge of understanding how the genome influences phenotype.
This approach has produced much information about how the genome influences recombination.
Moreover, we analyzed how selective pressures (quantified using relative entropy and dN/ dS), acting on the E. coli core genome, influenced lineage and phylogroup formation.
They concluded that DN affect virus replication because the nucleotide composition of the virus genome influences the host-cell innate response to the virus.
This is evident in Figure 4a, where the power of iHS is 0.74 when selective sweeps are very rare, 0.69 when 1% of the genome is influenced by positive selection, and drops to 0.33 when just 5% of the genome influenced by selection.
We have shown that the choice of reference genome influences the number of predictions involving proteins of previously unknown function, the accuracy of predicted interactions, and the topology of predicted interaction networks.
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