Exact(2)
Viral genome in brain tissue samples was examined by heminested pan-flaviviral reverse transcription PCR (7 ).
To our knowledge, no prior studies have compared the sequence of the entire mitochondrial genome in brain tumor cell lines with that of the syngeneic brain tissue.
Similar(58)
Here, we discuss the growing interest in the role of genome organization in brain development and neurological disorders.
These previous studies demonstrated the importance of genome maintenance in brain development but did not reveal the brain specific endogenous origins of DNA damage and its underlying molecular mechanisms.
This explains, in part, why scientists have had such a hard time finding the genetic underpinnings of neurological diseases: there isn't a standard genome in the brain.
Second, the bigger and more complex the brain gets, the larger the proportion of genes in the genome are involved in brain development.
CAT-3, encoded by the SLC7A3 gene on chromosome X, is one of the three CATs present in the human genome, with selective expression in brain.
The team's first step is to identify which genes are active in different regions of the brain -- a daunting task, since an estimated two-thirds of the mouse and human genomes play some role in brain activity.
Genome-wide gene expression in brain hippocampus was examined in a unique transgenic (Tg) mouse model that exhibits moderate Glu hyperactivity throughout the lifespan, the neuronal Glutamate dehydrogenase (Glud1) mouse, and littermate 9 month-old wild type mice.
In this issue of Epigenetics, Masliah et al. investigated genome-wide DNA methylation in brain and blood samples from Parkinson disease patients and observed a distinctive pattern of methylation involving many genes previously associated to the disease, supporting a role for epigenetic alterations as a molecular mechanism in neurodegeneration.
The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function.
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