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Pre-computed data for more than 300 cancer genome experiments are currently available.
A move from RRBS to whole genome bisulfite sequencing (WGBS) has already begun, though these whole genome experiments are much more expensive and still have significant alignment issues.
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As they see the whole genome experience, experiment, or they research all the DNA, they realize that this had to be created.
We show that while its SNV-calling performance is slightly less specific but more sensitive compared to Bis-SNP, MethylExtract performs better in methylation profiling, is easier to use and over twice as fast on a typical whole genome experiment.
We validated our approach using both target-capture and whole-genome experiments.
In addition to the whole-genome experiments with a maximum of five replicates, we simulated up to r = 15 replicates for the single chromosome arm.
An examination of the pathways and processes perturbed by whole-genome experiments allows those experimental results to be described in terms of their functional activity.
Many mutants used in this study produce viable progeny with polyploid genomes; experiments using these alleles were performed on homozygous worms produced by known diploid, heterozygous parents.
For our whole-genome experiment we used these three tools as well as GASVPro.
In a whole-genome experiment, LD between nearby markers and interactions between nearby selected SNPs are important confounders in identifying the selected markers.
For the whole-genome experiment we sequenced a diploid lymphobastoid cell-line from an anonymized female individual (Halper-Stromberg et al., 2011).
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