Sentence examples for genome effects from inspiring English sources

Zinc finger nucleases (ZFN) mediate transgene integration into the AAVS1 locus but comprehensive evaluation of off-target genome effects is currently lacking.

This allows for both a molecular analysis of brain genome effects and a behavioral analysis to demonstrate how both processes are affected.

However, there has been no systematic comparison of the whole genome effects of PPARα activation in human versus mouse hepatocytes [28].

There have been reports that in addition to PPARγ-mediated genome effects on genes important for maintaining vascular tone (including eNOS), PPARγ agonists may activate or inhibit ion channel activity in vessel walls directly.

The cytoplasmic genome was included as an additional marker to test for cytoplasmic genome effects.

Other genome effects have been previously modeled and explored [ 3], demonstrating loss of sensitivity with low selection and high recombination rates in the region.

All the genes considered, with the exceptions of the mitochondrially encoded Cox1 and Cox2 in Complex IV of the respiratory chain, are encoded by the nuclear genome, so a genome effect did not play a role in this result.

Genomic data are now used to infer either (1) whole-genome effects for the purpose of, e.g., estimation of breeding values to select superior breeding animals or for prediction of future phenotypes such as disease risks, or (2) effects of single genes or markers, to guide the development of human or veterinary drugs through improved knowledge on the biological basis of traits.

We also modeled all markers simultaneously to circumvent problems with false positive results and double counting of effects from correlated SNP, which was necessary to accumulate whole-genome effects.

This method quantifies the contribution of a specific genomic region to the heritability of a phenotype using a mixed model that includes random effects for a specific region and a residual whole-genome effect.

To understand the possible underlying mechanisms in the hippocampus, we performed a transcriptomic analysis and observed a whole-genome effect from the decrease in gene dosage associated with the App-Runx1 region.